First rate constants for reactions of OH radicals with amides

✍ Scribed by R. Koch; W.-U. Palm; C. Zetzsch

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 95 KB
• Volume: 29
• Category: Article
• ISSN: 0538-8066
• DOI: 10.1002/(sici)1097-4601(1997)29:2<81::aid-kin1>3.0.co;2-g

✦ Synopsis

dicted rate constants are invariably dominated by a 'Reaction with N'). While AOP treats amides as amines, we expect amides to be less reactive than amines from the analogous relationship between esters and ethers (see [3] for OH rate constants): if amines are matched to ethers (both are highly reactive against OH with negative activation energies), amides would correspond to the much less reactive esters (added carbonyl function with some delocalization of electrons).

The present work provides the first determination of OH rate constants for reaction with amides which may be used to investigate how much rate constants of amides may have been overestimated by treating them as amines [2], and whether it is possible to extend SARs to amides.

To serve this goal, four compounds showing a systematic variation of substituents have been selected with respect to the availability of sufficiently pure samples and manageable physical and chemical properties.