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First-pass effect after rectal administration of thiazinamium methylsulfate

✍ Scribed by J. H. G. Jonkman; L. E. van Bork; J. Wijsbeek; A. S. Bolhuis-De Vries; R. A. de Zeeuw; N. G. M. Orie; H. L. M. Cox

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 485 KB
Volume: 68
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600680121

No coin nor oath required. For personal study only.

✦ Synopsis

The absorption and metabolism of the quaternary ammonium compound thiazinamium methylsulfate were studied in humans using plasma concentration data and urinary excretion measurements. After giving a dose of 150 mg in suppositories, the relative bioavailability was 5.8 +/- 3.2 (SD) % of the dose, comparable to the values obtained following oral administration. The degree of first-pass effect observed after rectal administration was comparable with that after oral administration.

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