The absorption and metabolism of the quaternary ammonium compound thiazinamium methylsulfate were studied in humans using plasma concentration data and urinary excretion measurements. After giving a dose of 150 mg in suppositories, the relative bioavailability was 5.8 +/- 3.2 (SD) % of the dose, com
โฆ LIBER โฆ
Hepatic first-pass effect of thiazinamium methylsulfate (N-methylpromethazine methylsulfate) in dogs
โ Scribed by Jan H. G. Jonkman; Herman G. M. Westenberg; Eppo Van Der Kleyn
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 329 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0022-3549
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The pharmacokinetics of YH1885 were evaluated after intravenous (iv) and oral administrations of the drug to rats and dogs. The reason for the low extent of bioavailability (F) of YH1885 after oral administration of the drug to rats and the absorption of the drug from various rat gastrointestinal (G