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First Highly Regio- and Diastereoselective [3+2] Cycloaddition of Chiral Nonracemic Fischer Carbene Complexes with Azomethine Ylides: An Enantioselective Synthesis of (+)-Rolipram

✍ Scribed by José Barluenga; Manuel A. Fernández-Rodríguez; Enrique Aguilar; Félix Fernández-Marí; Alejandro Salinas; Bernardo Olano


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
34 KB
Volume
7
Category
Article
ISSN
0947-6539

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First Highly Regio- and Diastereoselecti
✍ José Barluenga; Manuel A. Fernández-Rodríguez; Enrique Aguilar; Félix Fernández- 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 213 KB 👁 2 views

A new procedure for the synthesis of 1,3,4-trisubstituted and 1,4-disubstituted pyrrolidin-2-one derivatives in an enantioselective fashion is reported. The 1,3-dipolar cycloaddition of (AE)menthol and (À)-8-phenylmenthol derived Fischer alkoxy alkenyl carbene complexes with in situ generated functi