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ChemInform Abstract: First Highly Regio- and Diastereoselective Synthesis of Δ2-Pyrazolines by [3 + 2] Cycloaddition of Chiral Non-Racemic Fischer Carbene Complexes with Nitrilimines.

✍ Scribed by J. BARLUENGA; F. FERNANDEZ-MARI; E. AGUILAR; A. L. VIADO; B. OLANO


Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
29
Category
Article
ISSN
0931-7597

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A new procedure for the synthesis of 1,3,4-trisubstituted and 1,4-disubstituted pyrrolidin-2-one derivatives in an enantioselective fashion is reported. The 1,3-dipolar cycloaddition of (AE)menthol and (À)-8-phenylmenthol derived Fischer alkoxy alkenyl carbene complexes with in situ generated functi