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Fibroblast Growth Factor-23 Is Regulated by 1α,25-Dihydroxyvitamin D

✍ Scribed by Michael T Collins; John R Lindsay; Alka Jain; Marilyn H Kelly; Carolee M Cutler; Lee S Weinstein; Jie Liu; Neal S Fedarko; Karen K Winer

Book ID
111485331
Publisher
American Society for Bone and Mineral Research
Year
2005
Tongue
English
Weight
153 KB
Volume
20
Category
Article
ISSN
0884-0431

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In X-linked hypophosphatemia (XLH) and in its murine homologue, the Hyp mouse, increased circulating concentrations of fibroblast growth factor 23 (FGF-23) are critical to the pathogenesis of disordered metabolism of phosphate (P(i)) and 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. In this study, we hypo