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REGULATION OF CYSTATHIONINE BETA SYNTHASE BY 1α,25-DIHYDROXYVITAMIN D3

✍ Scribed by Carsten Kriebitzsch; Lieve Verlinden; Guy Eelen; Kathleen Marchal; Bart DeMoor; Ine Beullens; Mark Van Camp; Roger Bouillon; Annemieke Verstuyf

Book ID
116322808
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
56 KB
Volume
46
Category
Article
ISSN
8756-3282

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1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine β-synthase
✍ Carsten Kriebitzsch; Lieve Verlinden; Guy Eelen; Natasja M van Schoor; Karin Swa 📂 Article 📅 2011 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 321 KB

High homocysteine (HCY) levels are a risk factor for osteoporotic fracture. Furthermore, bone quality and strength are compromised by elevated HCY owing to its negative impact on collagen maturation. HCY is cleared by cystathionine b-synthase (CBS), the first enzyme in the transsulfuration pathway.