1,25-dihydroxyvitamin D synthesis after renal transplantation: the role of fibroblast growth factor 23 and cyclosporine
β Scribed by Tetsuhiko Sato; Masafumi Fukagawa; Kazuharu Uchida; Akio Katayama; Takaharu Nagasaka; Susumu Matsuoka; Norihiko Goto; Yoshihiro Tominaga; Takaaki Kobayashi; Akimasa Nakao
- Book ID
- 110890138
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 527 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0902-0063
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In X-linked hypophosphatemia (XLH) and in its murine homologue, the Hyp mouse, increased circulating concentrations of fibroblast growth factor 23 (FGF-23) are critical to the pathogenesis of disordered metabolism of phosphate (P(i)) and 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. In this study, we hypo
## Abstract Leptin is the __LEP__ (__ob__) gene product secreted by adipocytes. We previously reported that leptin decreases renal expression of the 25βhydroxyvitamin D~3~ 1Ξ±βhydroxylase (__CYP27B1__) gene through the leptin receptor (ObRb) by indirectly acting on the proximal tubules. This study f