Fibroblast Growth Factor 23, Parathyroid Hormone, and 1α,25-Dihydroxyvitamin D in Surgically Treated Primary Hyperparathyroidism
✍ Scribed by Tebben, Peter J.; Singh, Ravinder J.; Clarke, Bart L.; Kumar, Rajiv
- Book ID
- 123490375
- Publisher
- Mayo Clinic
- Year
- 2004
- Tongue
- English
- Weight
- 177 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0025-6196
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## Abstract Leptin is the __LEP__ (__ob__) gene product secreted by adipocytes. We previously reported that leptin decreases renal expression of the 25‐hydroxyvitamin D~3~ 1α‐hydroxylase (__CYP27B1__) gene through the leptin receptor (ObRb) by indirectly acting on the proximal tubules. This study f
In X-linked hypophosphatemia (XLH) and in its murine homologue, the Hyp mouse, increased circulating concentrations of fibroblast growth factor 23 (FGF-23) are critical to the pathogenesis of disordered metabolism of phosphate (P(i)) and 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. In this study, we hypo