✦ LIBER ✦

Fatal adult case of severe lymphocytopenia associated with reactivation of human herpesvirus 6

✍ Scribed by Tetsushi Yoshikawa; Masaru Ihira; Yoshizo Asano; Akiko Tomitaka; Kayoko Suzuki; Kayoko Matsunaga; Yasuchika Kato; Sinya Hiramitsu; Tomohito Nagai; Naoko Tanaka; Hiroshi Kimura; Yukihiro Nishiyama

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 92 KB
Volume: 66
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.2114

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

It has been suggested that immunosuppression associated with human herpesvirus 6 (HHV‐6) infection is a result of functional impairment or direct destruction of immunological cells. The ability of the virus to infect and destroy lymphocytes may cause progressive immunodeficiency in an infant with primary HHV‐6 infection. An adult patient is described who had a fatal cytomegalovirus (CMV) infection due to severe and prolonged lymphocyte depletion associated with HHV‐6 reactivation. The HHV‐6 antibody titers were increased significantly after reactivation, and the virus was isolated from his peripheral blood mononuclear cells. The quantity of both HHV‐6 and CMV DNA was determined by using real‐time PCR in plasma samples collected serially. HHV‐6 DNAemia persisted for 1 month, which started just 1 week after the onset of lymphocytopenia. In contrast to HHV‐6, CMV DNAemia was detected in the terminal phase of the illness. Thus, HHV‐6 reactivation may have been the cause of the severe lymphocyte depletion and fatal CMV infection. J. Med. Virol. 66:82–85, 2002. © 2002 Wiley‐Liss, Inc.

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