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Fast atom bombardment positive-ion mass spectra of 1,2,2-tris(sulfonyl)hydrazines

✍ Scribed by Giuseppe Giordano; Krishnamurthy Shyam; Alan C. Sartorelli; Walter J. McMurray

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 313 KB
Volume: 27
Category: Article
ISSN: 1076-5174
DOI: 10.1002/oms.1210270518

No coin nor oath required. For personal study only.

✦ Synopsis

Several 1,2,2-tris(sulfonyl)hydrazines, conceived as prodrugs of 1,2bis(sulfonyl)hydra~nes and synthesized as potential antineoplastic and trypanocidal drugs, were analyzed by m a s spectrometry as part of the confirmation of the structure of these compounds. Since these compounds showed activity against several transplanted animal tumors, an understanding of the mass spectral behavior of these agents is important to gain information should clinical trials and metabolic studies be undertaken. In all spectra, protonated molecular ions were observed. Collision activation resulted in considerable fragmentation in the fast atom bombardment spectra. Rearrangement ions formed by elimination of substituted diimides from the middle of the molecule were observed. Other rearrangements involving the alkyl substituent and sulfonyl oxygen also occurred.

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