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Farnesyltransferase Inhibitors Inhibit the Growth of Malaria Parasites In Vitro and In Vivo

✍ Scribed by Jochen Wiesner; Katja Kettler; Jacek Sakowski; Regina Ortmann; Alejandro M. Katzin; Emília A. Kimura; Katrin Silber; Gerhard Klebe; Hassan Jomaa; Martin Schlitzer

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 127 KB
Volume: 43
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200351169

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✦ Synopsis

Farnesyltransferase catalyzes the posttranslational modification of numerous proteins involved in intracellular signal transduction by transferring the farnesyl residue of farnesyl pyrophosphate to the thiol of a cysteine side chain of the protein substrate. The cysteine residue belongs to a characteristic carboxy-terminal consensus sequence, the so-called

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