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Synthesis and In Vitro Evaluation of the Farnesyltransferase Inhibitor Pepticinnamin E

✍ Scribed by Klaus Hinterding; Patrizia Hagenbuch; Janos Rétey; Herbert Waldmann


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
206 KB
Volume
5
Category
Article
ISSN
0947-6539

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✍ Jochen Wiesner; Katja Kettler; Jacek Sakowski; Regina Ortmann; Alejandro M. Katz 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 127 KB 👁 1 views

Farnesyltransferase catalyzes the posttranslational modification of numerous proteins involved in intracellular signal transduction by transferring the farnesyl residue of farnesyl pyrophosphate to the thiol of a cysteine side chain of the protein substrate. The cysteine residue belongs to a charact