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Structurally Simple Farnesyltransferase Inhibitors Arrest the Growth of Malaria Parasites

✍ Scribed by Matthew P. Glenn; Sung-Youn Chang; Oliver Hucke; Christophe L. M. J. Verlinde; Kasey Rivas; Carrie Hornéy; Kohei Yokoyama; Frederick S. Buckner; Prakash R. Pendyala; Debopam Chakrabarti; Michael Gelb; Wesley C. Van Voorhis; Saïd M. Sebti; Andrew D. Hamilton

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 156 KB
Volume: 117
Category: Article
ISSN: 0044-8249
DOI: 10.1002/ange.200500674

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Farnesyltransferase catalyzes the posttranslational modification of numerous proteins involved in intracellular signal transduction by transferring the farnesyl residue of farnesyl pyrophosphate to the thiol of a cysteine side chain of the protein substrate. The cysteine residue belongs to a charact