Oncogenic mutations of the ras gene leading to constitutive activation of downstream effectors have been detected in a wide spectrum of human cancers (pancreas, thyroid, colon, non-small-cell lung cancer). Membrane anchorage of Ras, required for functional activity in signal transduction, is facilit
Inhibition of human tumor cell growth In vitro and In vivo by a specific inhibitor of human farnesyltransferase: BIM-46068
✍ Scribed by Grégoire P. Prevost; Anne Pradines; Isabelle Viossat; Marie-Christine Brezak; Karine Miquel; Marie-Odile Lonchampt; Philip Kasprzyk; Gilles Favre; Bernadette Pignol; Christine Le Breton; Jesse Dong; Barry Morgan
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- French
- Weight
- 69 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The GAS1 gene product induces growth arrest through a p53-dependent mechanism. To investigate whether GAS1 is a tumor suppressor gene, we transfected GAS1-negative human tumor cells with GAS1 plasmids and analyzed growth characteristics of stable transfectants. When a constitutively expressing GAS1
## Overexpression of the ErbB2 and epidermal growth factor receptor (EGFR) tyrosine kinases is frequently observed in squamous cell carcinomas of the head and neck, and has been correlated with shorter overall survival. By immunoblot analysis, we have found EGFR and ErbB2 expression in 6 out of 6 e
Bi-specific antibody fragments (bAB) are used in tumour therapy as a means to redirect and to strengthen effector cell function. It would be of great therapeutic advantage if, in addition, recruitment, expansion and the state of activity of effector cells are influenced by targeting through a bAB. T
Epithelial expression of the 75-kDa low-affinity neurotrophin receptor (p75 NTR ) is inversely associated with the malignant progression of the human prostate. To elucidate the function of p75 NTR in the prostate, the human prostate epithelial tumor cell line TSU-pr1, which does not express p75 NTR