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FANCJ Expression Predicts the Response to 5-Fluorouracil-Based Chemotherapy in MLH1-Proficient Colorectal Cancer

✍ Scribed by Ryota Nakanishi MD,Hiroyuki Kitao PhD…

Book ID
126393706
Publisher
Springer
Year
2012
Tongue
English
Weight
412 KB
Volume
19
Category
Article
ISSN
1068-9265

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has