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Gene expression profile of 5-fluorouracil metabolic enzymes in laryngeal cancer cell line: Predictive parameters for response to 5-fluorouracil-based chemotherapy

✍ Scribed by Galbiatti, Ana Lívia Silva; Caldas, Heloisa Cristina; Maniglia, José Victor; Pavarino, Érika Cristina; Goloni-Bertollo, Eny Maria


Book ID
122255679
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
832 KB
Volume
68
Category
Article
ISSN
0753-3322

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has