Familial adenomatous polyposis (FAP) is characterized by the presence of more than 100 colorectal adenomatous polyps with an almost inevitable progression to cancer. At-risk individuals are screened and, if affected, prophylactic colectomy is performed. Operative options include total colectomy with
Familial Adenomatous Polyposis and Extracolonic Cancer
โ Scribed by Henry T. Lynch; Alan G. Thorson; Rodney D. McComb; Barbara A. Franklin; Susan T. Tinley; Jane F. Lynch
- Book ID
- 110311855
- Publisher
- Springer US
- Year
- 2001
- Tongue
- English
- Weight
- 347 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0163-2116
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A 43-year-old man presented with a lung nodule 19 years after undergoing a total colectomy for familial adenomatous polyposis (FAP). There had been no evidence of malignant transformation in the colectomy specimen, and current gastrointestinal investigation did not reveal evidence of tumor. Patholog
Familial adenomatous polyposis (FAP) is a dominantly inherited familial cancer syndrome characterized by an increased predisposition to colorectal cancer and other benign and malignant extracolonic lesions. FAP has been linked to germline mutations of the adenomatous polyposis coli (APC) gene that e