Familial adenomatous polyposis and lung cancer
โ Scribed by Ralph P. Wong; Wel-Sek Hwang; Stephen K. Field
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 205 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0022-4790
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โฆ Synopsis
A 43-year-old man presented with a lung nodule 19 years after undergoing a total colectomy for familial adenomatous polyposis (FAP). There had been no evidence of malignant transformation in the colectomy specimen, and current gastrointestinal investigation did not reveal evidence of tumor. Pathological analysis of the lung nodule demonstrated adenocarcinoma of the lung of the fetal type. This is the first reported case of a lung neoplasm in a patient with FAP. The development of an unusual lung tumor in a patient with FAP, a condition associated with other extracolonic tumors, suggests that there may be an association between the two conditions.
๐ SIMILAR VOLUMES
Familial adenomatous polyposis (FAP) is a dominantly inherited familial cancer syndrome characterized by an increased predisposition to colorectal cancer and other benign and malignant extracolonic lesions. FAP has been linked to germline mutations of the adenomatous polyposis coli (APC) gene that e
Familial adenomatous polyposis (FAP) is characterized by the presence of more than 100 colorectal adenomatous polyps with an almost inevitable progression to cancer. At-risk individuals are screened and, if affected, prophylactic colectomy is performed. Operative options include total colectomy with