Risk of extracolonic cancer in familial adenomatous polyposis

✍ Scribed by K. P. Nugent; A. D. Spigelman; Mr R. K. S. Phillips

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 140 KB
• Volume: 83
• Category: Article
• ISSN: 0007-1323
• DOI: 10.1002/bjs.1800830828

✦ Synopsis

Familial adenomatous polyposis (FAP) is characterized by the presence of more than 100 colorectal adenomatous polyps with an almost inevitable progression to cancer. At-risk individuals are screened and, if affected, prophylactic colectomy is performed. Operative options include total colectomy with ileorectal anastomosis, which affords good functional results but leaves a risk of rectal cancer', and restorative proctocolectomy, which should eliminate the colorectal cancer risk at the expense of an increase in morbidity*. Patients with FAP are also at increased risk of developing a variety of extracolorectal cancers. This study addressed the relative impact of these cancers.