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Facile synthesis of thioglucose analogs of the anticancer agent etoposide

✍ Scribed by H.D. Hollis Showalterk; R.Thomas Winters; Anthony D. Sercel; Andrè Michel

Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
194 KB
Volume
32
Category
Article
ISSN
0040-4039

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The simple anthracycline analogues 3a-e were synthesized as potential anticancer agents. Anodic oxidation of the phenol derivative 4, phthalide anion annelation ofp-quinone monoacetals 5 and selective attachment of the side chain were the three key steps towards these target compounds.