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The synthesis of anthraquinone derivatives as potential anticancer agents

✍ Scribed by Ping Ge; Richard A. Russell

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
465 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

The simple anthracycline analogues 3a-e were synthesized as potential anticancer agents. Anodic oxidation of the phenol derivative 4, phthalide anion annelation ofp-quinone monoacetals 5 and selective attachment of the side chain were the three key steps towards these target compounds.

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Synthesis of Cycloruthenated Compounds a
Synthesis of Cycloruthenated Compounds as Potential Anticancer Agents
✍ Lida Leyva; Claude Sirlin; Laura Rubio; Cecilia Franco; Ronan Le Lagadec; John S πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 232 KB πŸ‘ 1 views

## Abstract A library of 19 cycloruthenated derivatives is constructed by making use of the well‐known cyclometalation reaction. Their geometries are modified in a straightforward manner by addition of either mono‐ or bidentate ligands, such as bipyridine, phenanthroline, 1,2‐bis(diphenylphosphanyl