The aim of this study was to characterize the metabolic pathways of 2methoxyestradiol (2ME2), an investigational anticancer drug. In vitro metabolism studies were performed by incubation of 2ME2 with human liver microsomes under various conditions and metabolite identification was performed using li
Instability of the anticancer agent etoposide under in vitro culture conditions
✍ Scribed by Robert M. Mader; Günther G. Steger; Kurt Moser; Hugo Rainer; Peter Krenmaryr; Christian Dittrich
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 652 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract In this paper the asymptotic behaviour of the solutions of __x' = A__(__t__)__x + h__(__t,x__) under the assumptions of instability is studied, __A__(__t__) and __h__(__t,x__) being a square matrix and a vector function, respectively. The conditions for the existence of bounded solution
## Abstract In vitro conditions affecting synthesis of sulfated proteoglycans by cell suspensions derived from monolayer cell cultures of normal and rheumatoid synovial tissue were examined. The capacity of cells to synthesize proteoglycans was estimated by the incorporation of ^35^S–sulfate into c
## Abstract A steady‐state model is presented of the metabolism of imipramine. In this model, the __N__‐demethylation and 2‐hydroxylation rates of imipramine were measured with and without the presence of metabolites by using a tritium isotope of imipramine. At an imipramine concentration of 5 μmol
1. Each half rete from five Boer goats was perfused with water at 38 1C and flow rate of 2 ml min À1 while simultaneously perfusing the cavernous sinus with water at different temperatures and flow combinations and recording temperatures across the rete. 2. The minimum temperature difference across