Radical cyclisation of (1) in the presence of Co(I) species leads to the cis-ring fused alkyl cobalt complex(6) which can be converted, in a preparative manner, into (8) following 1,2-elimination [to (7)] and hydrolysis/ oxidation, and into (12) following photo-oxygenation [to (15)], reduction [to (
Facile synthesis of functionalised spiroethers via radical cyclisations
โ Scribed by Donald S. Middleton; Nigel S. Simpkins; Nicholas K. Terrett
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 237 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
โฆ Synopsis
Alcohols bearing suitable chains for radical initiation are smoothly condensed with cyclic Pdiketones to afford systems which undergo radical cyclisation to give various spircether products.
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