✦ LIBER ✦
Oxidative free-radical cyclisations via cobalt (I) reagents. Novel approach to functionalised butyrolactones.
✍ Scribed by Harcharan Bhandal; Gerald Pattenden; Jamie J. Russell
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 231 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Radical cyclisation of (1) in the presence of Co(I) species leads to the cis-ring fused alkyl cobalt complex(6) which can be converted, in a preparative manner, into (8) following 1,2-elimination [to (7)] and hydrolysis/ oxidation, and into (12) following photo-oxygenation [to (15)], reduction [to (16)], and hydrolysis/oxidation.
The overwhelming majority of free radical cyclisation reactions are performed under reductive conditions, with the result that ring formation