Facile synthesis of (+)-brefeldin A
β Scribed by Junzo Nokami; Mamoru Ohkura; Yasufumi Dan-Oh; Yasuhiko Sakamoto
- Book ID
- 104216297
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 262 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
An effective and enantioselective process for the total synthesis of (+)-brefeldin A (1) is described which start8 from the dextrorotatory ketone 2. Bmfeldin Al (1) has long been known to exhibit an extraordinary range of biological activities including antibiotic, antiviral, cytostatic and antimit
A formal synthesis of (+)-brefeldin A has been achieved v/a stereoselective construction of hydroxycyclopentane skeleton possessing the requisite hydroxyheptenyl side chain. The highly advanced intermediate 2 has been synthesized from the known Weinreb amide in 19 % overall yield of 11 steps.