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Facile synthesis of (+)-brefeldin A

✍ Scribed by Junzo Nokami; Mamoru Ohkura; Yasufumi Dan-Oh; Yasuhiko Sakamoto


Book ID
104216297
Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
262 KB
Volume
32
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


A synthesis of brefeldin A
✍ R. Baudouy; P. CrabbΓ©; A.E. Greene; C. Le Drian; A.F. Orr πŸ“‚ Article πŸ“… 1977 πŸ› Elsevier Science 🌐 French βš– 220 KB
A synthesis of (Β±)-brefeldin A
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Total Synthesis of (+)-Brefeldin A.
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Total synthesis of (Β±)-brefeldin A
✍ E.J. Corey; Robert H. Wollenberg πŸ“‚ Article πŸ“… 1976 πŸ› Elsevier Science 🌐 French βš– 237 KB
A simplified synthesis of (+)-brefeldin
✍ E.J. Corey; Philip Carpino πŸ“‚ Article πŸ“… 1990 πŸ› Elsevier Science 🌐 French βš– 226 KB

An effective and enantioselective process for the total synthesis of (+)-brefeldin A (1) is described which start8 from the dextrorotatory ketone 2. Bmfeldin Al (1) has long been known to exhibit an extraordinary range of biological activities including antibiotic, antiviral, cytostatic and antimit

A formal synthesis of (+)-brefeldin A
✍ Young-Ger Suh; Jae-Kyung Jung; Byung-Chul Suh; Young-Choon Lee; Soon-Ai Kim πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 213 KB

A formal synthesis of (+)-brefeldin A has been achieved v/a stereoselective construction of hydroxycyclopentane skeleton possessing the requisite hydroxyheptenyl side chain. The highly advanced intermediate 2 has been synthesized from the known Weinreb amide in 19 % overall yield of 11 steps.