Total synthesis of (±)-brefeldin A
✍ Scribed by E.J. Corey; Robert H. Wollenberg
- Book ID
- 108382106
- Publisher
- Elsevier Science
- Year
- 1976
- Tongue
- French
- Weight
- 237 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
A key intermediate, a substituted cyclopentanonitrile (10) with correct stereochemistry. was prepared from D-mannitol and converted to the Corey's intermexate (27) without a C15-epimer, which was finally transformed to (+)-brefeldin A. (+)-Brefeldin A (l), is;La:ed from a variety of fungi by several
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Rrefeldin A (9 is a macrocyclic fungal metabolite which exhibits both antibiotic and antiviral activity. A route for the total synthesis of this substance in racemic form has recently been established and reported from these laboratories. ' This note describes modifications in the synthetic sequenc