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Total Synthesis of (+)-Brefeldin A.

โœ Scribed by Young-Ger Suh; Jae-Kyung Jung; Seung-Yong Seo; Kyung-Hoon Min; Dong-Yun Shin; Yong-Sil Lee; Seok-Ho Kim; Hyun-Ju Park


Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
33
Category
Article
ISSN
0931-7597

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A Formal Synthesis of (+)-Brefeldin A. -An advanced synthetic intermediate for (+)-brefeldin A (IX) is efficiently synthesized from Weinreb amide (I). The procedure involves the highly stereoselective construction of the hydroxycyclopentane moiety via an oxabicycloheptanone unit. -(SUH,