Asymmetric Total Synthesis of the Macrolides Brefeldin A and 7-epi-Brefeldin A
β Scribed by Priv.-Doz. Dr. Hans-Joachim Gais; Dr. Thomas Lied
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 244 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0044-8249
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π SIMILAR VOLUMES
A Formal Synthesis of (+)-Brefeldin A. -An advanced synthetic intermediate for (+)-brefeldin A (IX) is efficiently synthesized from Weinreb amide (I). The procedure involves the highly stereoselective construction of the hydroxycyclopentane moiety via an oxabicycloheptanone unit. -(SUH,
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Enantioconvergent Formal Synthesis of Brefeldin A via Sakai-Catalyzed Cyclization. -A formal total synthesis of the antitumor agent brefeldin A (XII) is presented by asymmetric synthesis of intermediate (XI). Key steps are the asymmetric Sakai cyclization of racemic pentenal (I) and the reductive a