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ChemInform Abstract: Enantioconvergent Formal Synthesis of Brefeldin A via Sakai-Catalyzed Cyclization.

✍ Scribed by Pierre Ducray; Bernard Rousseau; Charles Mioskowski

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Enantioconvergent Formal Synthesis of Brefeldin A via Sakai-Catalyzed Cyclization.

-A formal total synthesis of the antitumor agent brefeldin A (XII) is presented by asymmetric synthesis of intermediate (XI). Key steps are the asymmetric Sakai cyclization of racemic pentenal (I) and the reductive alkylation of epoxide (IX). -(DUCRAY, PIERRE;

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