2-Bromo-3,3,3-trifluoropropene: A Facile Trifluoromethylacetylene Anion Synthon. -Use of 2-bromo-3,3,3-trifluoropropene (I) provides a convenient and high yielding method to introduce a trifluoromethylethynyl moiety into a wide range of organic substrates (→ (III); 8 examples). -
Facile Synthesis of 2,3-Diiodonaphthalene and 2-Bromo-3-iodonaphthalene.
✍ Scribed by Jonas Hellberg; Fredrik Allared; Margit Pelcam
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 82 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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## Abstract The 2′‐deoxyisoguanosine (1) was synthesized by a two‐step procedure from 2′‐deoxyguanosine (5). Amination of silylated 2′‐deoxyguanosine yielded 2‐amino‐2′‐deoxyadenosine (6) which was subjected to selective deamination of the 2‐NH~2~ group resulting in compound 1. Also 2′,3′‐dideoxyis
a b s t r a c t 2,3-Azaisoindoline (4) was prepared via reaction of dichloride 11 with 2,4-dimethoxybenzyl amine followed by deprotection with trifluoroacetic acid and triethylsilane. Isolation of the unstable 2,3-azaisoindoline 4 was facilitated by conversion to the bis-HCl salt.
In a three-step sequence starting from readily available starting materials, 2,3-carbon disubstituted furo[2,3-b]pyridines can be accessed in good yields and purity. Furo[2,3-b]pyridines bearing ester, amide and ketone groups at the 2-position can be prepared with a variety of aryl and alkyl groups