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A facile synthesis of 2,3-azaisoindoline

✍ Scribed by Subas M. Sakya; Michel Van Den Berg; Kees Pouwer; John M. Humphrey; Christopher J. Helal; Christopher J. O’Donnell

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
358 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

a b s t r a c t 2,3-Azaisoindoline (4) was prepared via reaction of dichloride 11 with 2,4-dimethoxybenzyl amine followed by deprotection with trifluoroacetic acid and triethylsilane. Isolation of the unstable 2,3-azaisoindoline 4 was facilitated by conversion to the bis-HCl salt.

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A facile synthesis of 2,3-disubstituted
A facile synthesis of 2,3-disubstituted furo[2,3-b]pyridines
✍ Gregory L. Beutner; Jeffrey T. Kuethe; Nobuyoshi Yasuda 📂 Article 📅 2009 🏛 Elsevier Science 🌐 French ⚖ 174 KB

In a three-step sequence starting from readily available starting materials, 2,3-carbon disubstituted furo[2,3-b]pyridines can be accessed in good yields and purity. Furo[2,3-b]pyridines bearing ester, amide and ketone groups at the 2-position can be prepared with a variety of aryl and alkyl groups