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Facile and regioselective synthesis of novel 2,4-disubstituted-5-fluoropyrimidines as potential kinase inhibitors

✍ Scribed by Hiroki Wada; Lili Cheng; Ji Jiang; Zhigan Jiang; Jun Xie; Tao Hu; Hitesh Sanganee; Tim Luker


Book ID
113930553
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
776 KB
Volume
53
Category
Article
ISSN
0040-4039

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## Abstract The reaction of hydrazide with carbonyl chloride in the presence of sodium carbonates leads to the corresponding 1,2‐diacylhydrazines [**1a**–**t**, R^1^C(O)NHNHC(O)R^2^, R^1^ = aryl, R^2^ = aryl or alkyl] in moderate to excellent yield (57–90 %). The latter reacts with 2,4‐diphenyl‐1,3