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Asymmetric Synthesis of 4,6-Disubstituted 1,2,3,4,5,6-Hexahydro-5-hydroxypyrimidin-2-ones as Potential HIV-Protease-Inhibitors.

✍ Scribed by Dieter Enders; Lars Wortmann

Publisher
John Wiley and Sons
Year
2003
Weight
129 KB
Volume
34
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

For Abstract see ChemInform Abstract in Full Text.

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Asymmetric Synthesis of 1,2,3,4,5,6-Hexa
Asymmetric Synthesis of 1,2,3,4,5,6-Hexahydro-5-hydroxypyrimidin-2-ones as Potential HIV-Protease Inhibitors
✍ Dieter Enders; Lars Wortmann; Barbara DΓΌcker; Gerhard Raabe πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 German βš– 101 KB πŸ‘ 1 views

The first asymmetric synthesis of potential cyclic urea HIV protease inhibitors of Type 2 is reported. The synthesis is short and highly versatile in the choice of the substitution pattern and absolute configuration of the products starting from readily available materials. Nonchiral central buildin