The first asymmetric synthesis of potential cyclic urea HIV protease inhibitors of Type 2 is reported. The synthesis is short and highly versatile in the choice of the substitution pattern and absolute configuration of the products starting from readily available materials. Nonchiral central buildin
ChemInform Abstract: Asymmetric Synthesis of 1,2,3,4,5,6-Hexahydro-5-hydroxypyrimidin-2-ones as Potential HIV-Protease Inhibitors.
β Scribed by Dieter Enders; Lars Wortmann; Barbara Duecker; Gerhard Raabe
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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Nonpeptidic HIV Protease Inhibitors: 6-Alkyl-5,6-dihydropyran-2-ones Possessing a Novel and Achiral 3-(2-t-Butyl-5-methyl-4sulfamate)phenylthio Moiety. -With the introduction of a sulfamate moiety, a new template is created which shows HIV protease binding affinity. An alkyl group at the 6-position