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ChemInform Abstract: Nonpeptidic HIV Protease Inhibitors: 6-Alkyl-5,6-dihydropyran-2-ones Possessing a Novel and Achiral 3-(2-t-Butyl-5-methyl-4-sulfamate)phenylthio Moiety.

✍ Scribed by J. V. N. Vara Prasad; et al. et al.

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199946145

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✦ Synopsis

Nonpeptidic HIV Protease Inhibitors: 6-Alkyl-5,6-dihydropyran-2-ones Possessing a Novel and Achiral 3-(2-t-Butyl-5-methyl-4sulfamate)phenylthio Moiety.

-With the introduction of a sulfamate moiety, a new template is created which shows HIV protease binding affinity. An alkyl group at the 6-position of the dihydropyran ring seems to be necessary for the desired activity. -(

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✍ J. V. N. Vara Prasad; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB