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Asymmetric Synthesis of 4,6-Disubstituted 1,2,3,4,5,6-Hexahydro-5-hydroxypyrimidin-2-ones as Potential HIV-Protease-Inhibitors

✍ Scribed by Enders, Dieter; Wortmann, Lars


Book ID
121665564
Publisher
Japan Institute of Heterocyclic Chemistry
Year
2002
Tongue
English
Weight
276 KB
Volume
58
Category
Article
ISSN
0385-5414

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Asymmetric Synthesis of 1,2,3,4,5,6-Hexa
✍ Dieter Enders; Lars Wortmann; Barbara DΓΌcker; Gerhard Raabe πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 German βš– 101 KB πŸ‘ 1 views

The first asymmetric synthesis of potential cyclic urea HIV protease inhibitors of Type 2 is reported. The synthesis is short and highly versatile in the choice of the substitution pattern and absolute configuration of the products starting from readily available materials. Nonchiral central buildin