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A Highly Flexible Route to 1,2,3,4,5,6- Hexahydro-5-hydroxypyrimidin-2-ones as Potential HIV Protease Inhibitors

✍ Scribed by Enders, Dieter; Wortmann, Lars; Raabe, Gerhard; Dücker, Barbara


Book ID
121665565
Publisher
Japan Institute of Heterocyclic Chemistry
Year
2004
Tongue
English
Weight
239 KB
Volume
62
Category
Article
ISSN
0385-5414

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Asymmetric Synthesis of 1,2,3,4,5,6-Hexa
✍ Dieter Enders; Lars Wortmann; Barbara Dücker; Gerhard Raabe 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 German ⚖ 101 KB 👁 1 views

The first asymmetric synthesis of potential cyclic urea HIV protease inhibitors of Type 2 is reported. The synthesis is short and highly versatile in the choice of the substitution pattern and absolute configuration of the products starting from readily available materials. Nonchiral central buildin