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Expression of the hepatocyte growth factor and c-MET genes during furan-induced regenerative cell proliferation in the livers of B6C3F1 mice and F-344 rats

โœ Scribed by C. S. Sprankle; T. L. Goldsworthy; S. M. Goldsworthy; D. M. Wilson; B. E. Butterworth

Book ID
114716051
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
755 KB
Volume
27
Category
Article
ISSN
0960-7722

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โœ Byron E. Butterworth; Catherine S. Sprankle; Susan M. Goldsworthy; Daniel M. Wil ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 867 KB

## Abstract Furan administered by gavage for 2 yr has been reported to induce hepatocellular carcinomas in male and female B6C3F~1~ mice and in male but not female F344 rats. Chronic exposure studies in our laboratory using bioassay conditions showed extensive hepatocellular toxicity and sustained