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Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F1 mice

✍ Scribed by Ming W. Chou; Jian Yan; Jasyl Nichols; Qingsu Xia; Frederick A. Beland; Po-Cheun Chan; Peter P. Fu

Book ID
117467709
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
143 KB
Volume
193
Category
Article
ISSN
0304-3835

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Glycidol, a simple aliphatic epoxide, was administered by gavage in water to groups of male and female F344/N rats and B6C3F1 mice. Rats received 0, 37.5 or 75 mg kg-' and mice received 0, 25 or 50 mg kg-' daily, 5 days per week for 2 years. Exposure to glycidol was associated with dose-related incr