𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Carcinogenicity of Glycidol in F344 Rats and B6C3F1 Mice

✍ Scribed by Richard D. Irwin; Scot L. Eustis; Steven Stefanski; Joseph K. Haseman

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
740 KB
Volume
16
Category
Article
ISSN
0260-437X

No coin nor oath required. For personal study only.

✦ Synopsis

Glycidol, a simple aliphatic epoxide, was administered by gavage in water to groups of male and female F344/N rats and B6C3F1 mice. Rats received 0, 37.5 or 75 mg kg-' and mice received 0, 25 or 50 mg kg-' daily, 5 days per week for 2 years. Exposure to glycidol was associated with dose-related increases in the incidences of neoplasms in numerous tissues in both rats and mice. Survival of rats that received glycidol was markedly reduced compared to the control because of the early induction of neoplastic disease. In male rats, mesothelioma arising in the tunica vaginalis and frequently metastasizing to the peritoneum were considered the major cause of early death. Early deaths in female rats were associated with mammary gland neoplasms. Survival of female mice that received 50 mg kg-' was lower than the control after week 101 due primarily to euthanasia of moribund animals with mammary gland neoplasms. Survival of male mice and female mice that received 25 mg kg-' was comparable to the control. In mice, exposure to glycidol was associated with increased incidences of neoplasms of the harderian gland in males and females, the forestomach in males and the mammary gland in females.

πŸ“œ SIMILAR VOLUMES

Carcinogenicity of dermally administered
Carcinogenicity of dermally administered 1,2-Dihydro-2,2,4-trimethylquinoline monomer in F344 rats and B6C3F1 mice
✍ Richard D. Irwin; John E. French; Michael Elwell; Joe Haseman; A. G. Braun; F. A πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 76 KB πŸ‘ 1 views

1,2-Dihydro-2,2,4-trimethylquinoline (TMQ) was evaluated in a 2-year study in which groups of 60 male or female F344 rats received 0, 36 or 60 mg kg ؊1 (0, 0.022, or 0.037 mg cm ؊2 ) and groups of 60 male or female B6C3F 1 mice received 0, 3.6 or 10 mg kg ؊1 (0, 0.00136, 0.00435 mg cm ؊2 ) in aceton

Toxicity of Furfuryl Alcohol to F344 Rat
Toxicity of Furfuryl Alcohol to F344 Rats and B6C3F1 Mice Exposed by Inhalation
✍ Richard D. Irwin; B. J. Chou; P. W. Mellick; R. A. Miller; Joel Mahler; Joe Royc πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 477 KB πŸ‘ 1 views

Groups of F344 rats and B6C3F 1 mice were exposed to furfuryl alcohol vapor for 6 hours per day, 5 days per week for 14 days (0, 16, 31, 63, 125, 250 ppm) or 13 weeks (0, 2, 4, 8, 16, 32 ppm). Reduced survival was observed in the 14-day study at 250 ppm. Final mean body weights of rats and mice expo

Carcinogenicity study of GSM and DCS wir
Carcinogenicity study of GSM and DCS wireless communication signals in B6C3F1 mice
✍ Thomas Tillmann; Heinrich Ernst; Sven Ebert; Niels Kuster; Wolfgang Behnke; Susa πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 244 KB πŸ‘ 1 views

## Abstract The purpose of this study using a total of 1170 B6C3F1 mice was to detect and evaluate possible carcinogenic effects in mice exposed to radio‐frequency‐radiation (RFR) from Global System for Mobile Communication (GSM) and Digital Personal Communications System (DCS) handsets as emitted

Toxicokinetics of bromodichloroacetate i
Toxicokinetics of bromodichloroacetate in B6C3F1 mice
✍ J. L. Merdink; R. J. Bull; I. R. Schultz πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 60 KB

## Abstract The oral and i.v. elimination kinetics were investigated for bromodichloroacetate (BDCA), a haloacetate found in drinking water. The BDCA was administered at a dose of 5, 20 and 100 mg kg^βˆ’1^ to B6C3F1 mice and appears to distribute to the total body water with a mean volume of distribu