Expression of Stat3 and indoleamine 2, 3-dioxygenase in cornea keratocytes as factor of ocular immune privilege
✍ Scribed by Jae Wook Yang; Dong Sik Ham; Hyun Woong Kim; Sul Gee Lee; Sae Kwang Park; Su Kil Seo
- Publisher
- Springer-Verlag
- Year
- 2011
- Tongue
- English
- Weight
- 288 KB
- Volume
- 250
- Category
- Article
- ISSN
- 0065-6100
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## Abstract Indoleamine 2,3‐dioxygenase (IDO), a tryptophan‐catabolizing enzyme, is an intracellular enzyme possessing various immunosuppressive properties. Here, we report the possible use of this enzyme to suppress proliferation of immune cells cocultured with IDO‐expressing fibroblasts of an all
Alterations in the rate of cellular tryptophan metabolism are involved in mediating important biological activities associated with cytokines and growth factors. Indoleamine 2,3-dioxygenase (IDO) and tryptophanyl-tRNA synthetase are enzymes of tryptophan metabolism whose expression in a variety of c