Alterations in the rate of cellular tryptophan metabolism are involved in mediating important biological activities associated with cytokines and growth factors. Indoleamine 2,3-dioxygenase (IDO) and tryptophanyl-tRNA synthetase are enzymes of tryptophan metabolism whose expression in a variety of c
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Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression
✍ Scribed by Sven C. Beutelspacher; Radhakrishna Pillai; Martin P. Watson; Peng H. Tan; Julia Tsang; Myra O. McClure; Andrew J. T. George; Daniel F. P. Larkin
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 359 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0014-2980
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## Abstract In several human cancers, ErbB2 over‐expression facilitates the formation of constitutively active homodimers resistant to internalization which results in progressive signal amplification from the receptor, conducive to cell survival, proliferation, or metastasis. Here we report on stu