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Expression of pSTAT5 predictsFLT3internal tandem duplications in acute myeloid leukemia

✍ Scribed by Ellen Christina Obermann; Caroline Arber; Martine Jotterand; Andre Tichelli; Petra Hirschmann; Alexandar Tzankov


Book ID
105989534
Publisher
Springer
Year
2010
Tongue
English
Weight
340 KB
Volume
89
Category
Article
ISSN
0939-5555

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## Abstract ## BACKGROUND Recently, an internal tandem duplication of the __FLT3__ gene (__FLT3__/ITD) was found in approximately 20% of adult acute myeloid leukemia (AML) cases and associated with a poor outcome. However, there are few studies on __FLT3__/ITD in childhood AML, and the clinical si

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## Abstract Partial tandem duplication (PTD) of the __MLL__ gene and internal tandem duplication (ITD) of the juxtamembrane region of the __FLT3__ receptor tyrosine kinase gene have been described in acute myeloid leukemia (AML) patients, preferentially in those with normal cytogenetics. These alte