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Expression of p16INK4Agene in human pituitary tumours

โœ Scribed by Gloria Machiavelli; Javier Cotignola; Karina Danilowicz; Carolina Carbonara; Andrea Paes de Lima; Armando Basso; Oscar Domingo Bruno; Irene Szijan

Book ID
106497272
Publisher
Springer US
Year
2007
Tongue
English
Weight
173 KB
Volume
11
Category
Article
ISSN
1386-341X

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## Abstract Upregulation of the p16 tumor suppressor is a hallmark of senescence in human fibroblasts. In this study, we investigated potential protein modification of p16 in senescent human fibroblasts using 2D SDSโ€“PAGE analysis. Three distinct p16 variants with isoelectric points of 5.2, 5.4, and