Effects of exogenous p16ink4agene on biological behaviors of human lung cancer cells
โ Scribed by Xiaoju Zhang; Yang Jin; Xiaonan Tao; Ming Bai
- Book ID
- 107405510
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- Chinese
- Weight
- 80 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0510-9752
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The p p ! 6INK4 and p I8 genes are members of the gene famil coding for inhibitors of cyclin-dependent kinases 4 and 6. frequently deleted in many human neoplasms. To examine the role of these 3 genes in lung carcinogenesis, somatic mutations within the genes were analyzed by single-strand conformat
Inactivation of p16(INK4a) in the Rb pathway is among the most common somatic alterations observed in nonsmall cell lung cancers (NSCLCs). While epigenetic inactivation of the p16(INK4a) gene promoter has been shown to be associated with increased tobacco carcinogen exposure, little investigation of