Expression of Epstein–Barr-virus-encoded small nuclear RNA in nasopharyngeal carcinomas of Aegean Turkish patients
✍ Scribed by Yeşim Ertan; Mine Hekimgil; Serap Karaarslan; Saliha Soydan
- Book ID
- 106117939
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 177 KB
- Volume
- 452
- Category
- Article
- ISSN
- 1432-2307
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The authors thank Drs. Anthony J. Janckila and Lung T. Yam of the University of Louisville, Louisville, Kentucky, for their criticism of this article. They also would like to thank Miss Su-Huei Lee for her excellent technique for in situ hybridization and immunohistochemical stainings.
## Abstract It has been generally believed that the Epstein–Barr virus (EBV)‐encoded small RNA 1 and 2 (EBER1 and EBER2) genes are conserved as two families that correlated with type 1 (B95‐8) and type 2 (AG876 or P3HR‐1) EBV strains. EBER polymorphism and its association with EBV‐associated diseas
## RESULTS. In specimens from 107 patients with NPC, EBV was detected by PCR in 2 Department of Pathology, the Johns Hopkins 97 cases (90.7%) and by EBER in situ hybridization in 105 cases (98.1%). In speci-
Epstein-Barr virus (EBV)-encoded RNAs (EBERs) are the most abundant viral transcripts in latently EBV-infected cells. Recently, we found that EBERs play a key role in the maintenance of malignant phenotypes of Burkitt's lymphoma (BL) cells. They confer clonability in soft agarose, tumorigenicity in