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The role of Epstein–Barr virus-encoded small RNAs (EBERs) in oncogenesis

✍ Scribed by Asuka Nanbo; Kenzo Takada

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
172 KB
Volume
12
Category
Article
ISSN
1052-9276

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✦ Synopsis

Epstein-Barr virus (EBV)-encoded RNAs (EBERs) are the most abundant viral transcripts in latently EBV-infected cells. Recently, we found that EBERs play a key role in the maintenance of malignant phenotypes of Burkitt's lymphoma (BL) cells. They confer clonability in soft agarose, tumorigenicity in immunodeficient mice, resistance to apoptosis and induction of interleukin (IL)-10, which acts as an autocrine growth factor of BL cells. Furthermore, we demonstrated that EBERs confer resistance to interferon (IFN)-alpha-induced apoptosis by inhibition of double-stranded (ds) RNA-activated protein kinase (PKR), which is the key mediator of the antiviral effect of IFN-alpha. These studies provide a new notion that RNA molecules contribute to oncogenesis.

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