✦ LIBER ✦

ABSENCE OF EPSTEIN-BARR VIRAL ENCODED RNA (EBER) IN PRIMARY CUTANEOUS T-CELL LYMPHOMA

✍ Scribed by ANGEL, CAROLE A.; SLATER, DAVID N.; ROYDS, JANICE A.; NELSON, STUART N. P.; BLEEHEN, STANLEY S.

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 298 KB
Volume: 178
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199602)178:2<173::aid-path428>3.0.co;2-y

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✦ Synopsis

Epstein-Barr virus (EBV) has been associated with various extracutaneous lymphoproliferative diseases and it has been suggested that EBV may have a similar aetiological role in cutaneous T-cell lymphoma. In this study, in situ hybridization was used to investigate the presence of EBV encoded RNAs (EBER-1 and EBER-2) in 37 biopsies from 28 cases of primary cutaneous T-cell lymphoma originating from the U.K. The results showed that EBV had no demonstrable pathogenic role in the lymphomas studied, as EBER was not detected in any case. KEY WORDS-Epstein-Barr virus; EBER; cutaneous lymphoma; mycosis fungoides; in situ hybridization

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