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Expression of cyclin-dependent kinase inhibitor p15INK4B during normal and leukemic myeloid differentiation

✍ Scribed by Luciana Teofili; Roberta Morosetti; Maurizio Martini; Raffaella Urbano; Rossana Putzulu; Sergio Rutella; Luca Pierelli; Giuseppe Leone; Luigi Maria Larocca

Book ID: 114216117
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 648 KB
Volume: 28
Category: Article
ISSN: 0301-472X
DOI: 10.1016/s0301-472x(00)00139-9

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## Background: D-type cyclins, in association with the cyclin-dependent kinases cdk4 and cdk6, promote progression through the g1 phase of the cell cycle. cdk activity is modulated by inhibitors such as p15ink4b and p16ink4a. loss of function of p15ink4b and p16ink4a (multiple tumor suppressor-i an